Can I get it?
Yes, if a doctor decides it is right for you. Tretinoin 0.05% is authorised in the EU and can be prescribed after a medical review.
Tretinoin 0.05% · OviedoPrescription only
Online medical consultation for Tretinoin 0.05% in Oviedo.
An EU-licensed doctor reviews your case and, if eligible, issues an electronic prescription valid in any pharmacy in Spain. Consultation €35, refunded if the doctor decides it is not safe to prescribe.
- A pea-sized amount at night on dry skin
- The retinoid with the longest photoageing evidence record
- Contraindicated in pregnancy; SPF 50+ every morning
Start consultationStart consultation · €35
Full refund if a review is not approved · Medication, if prescribed, is dispensed and paid for separately at a pharmacy.
IN PLAIN TERMS
What Tretinoin 0.05% is, and how to get treatment
Tretinoin is vitamin-A acid, and it exists as two very different medicines. As a cream or gel it is applied to the skin for acne, where it clears blocked pores. As a capsule taken by mouth it is a hospital cancer treatment for acute promyelocytic leukaemia, given under haematology supervision — the same molecule, a completely different setting and dose. Both are real, authorised medicines; neither is something Hi-Doctor prescribes, because we treat hair loss, weight management and sexual health.
Tretinoin 0.05% is an authorised medicine in the EU, so a licensed doctor can prescribe it when it is clinically appropriate for you.
What can I take instead?
Our doctors review every Dermatology option and recommend what fits your history and goals.
See all Dermatology optionsWhat do the studies show?
Every trial behind Tretinoin 0.05% is listed below with how many people took part and whether the results are peer-reviewed or a company announcement.
Jump to the studiesLocal consultation facts
Can I get Tretinoin 0.05% in Oviedo?
Yes. People in Oviedo, Spain, can request an online doctor consultation about Tretinoin 0.05% with Hi-Doctor. A licensed EU doctor reviews the case and issues a prescription only when clinically appropriate. If approved, the electronic prescription arrives as a QR code that can be dispensed directly in Spain.
Availability
Tretinoin 0.05% is available to residents of Spain through the online consultation. A prescription follows only if the doctor approves it.
- Country
- Spain
- Language of service
- Spanish and English
- Prescription turnaround
- In less than 4 hours on average, only if the doctor approves
- Honoured locally
- QR electronic prescription, dispensed directly in Spain
How the EU prescription works where you are: In Spain, an approved prescription arrives electronically with a QR code for direct dispensing.
VERIFIED EVIDENCE
Tretinoin 0.05%: evidence and regulatory guide.
WHAT IT IS
How it works
Topical retinoic acid that binds retinoid receptors in the skin, normalising cell turnover, dispersing pigment and increasing dermal collagen formation over months.
- retinoic acid receptor (RAR)
DEVELOPMENT STAGE
EU-authorised medicine
Trial register2 registered trials
Every NCT identifier links to its ClinicalTrials.gov record. A readout is not the same as peer-reviewed publication.
| TRIAL / NCT | POPULATION | PARTICIPANTS | STATUS | READOUT / COMPLETION |
|---|---|---|---|---|
| Weiss 1988 (tretinoin 0.1% cream vs vehicle, photoaged skin) | Adults with photoaged facial and forearm skin, 16 weeks, double-blind | — | Read out | 1988 |
| Kang 2005 (tretinoin emollient cream 0.05% vs placebo, 2 years) | Adults with moderate to severe facial photodamage, once daily for up to 2 years | 204 | Read out | 2005 |
What the studies reported
Results are grouped by source and evidence grade so journal data and manufacturer announcements cannot be confused.
Peer-reviewed
Kang S et al. Am J Clin Dermatol 2005;6(4):245-253 · DOI: 10.2165/00128071-200506040-00005| DOSE OR GROUP | MEAN WEIGHT CHANGE | WEEKS |
|---|---|---|
| Tretinoin 0.05% emollient cream, once daily | Significantly greater improvement than placebo in fine and coarse wrinkling, mottled hyperpigmentation, lentigines, sallowness and overall photodamage | 104 |
| Placebo (vehicle emollient cream) | Reference | 104 |
Improvements are graded clinical changes, not a return to unexposed skin, and they depend on continued use. The Spanish authorisation of tretinoin 0.05% cream (Retirides, AEMPS FT 60141) covers both acne and adjunctive treatment of photoageing and is supported by this and other randomised trials.
Peer-reviewed
Weiss JS et al. JAMA 1988;259(4):527-532| DOSE OR GROUP | MEAN WEIGHT CHANGE | WEEKS |
|---|---|---|
| Tretinoin 0.1% cream, nightly | Improvement in photoaged skin versus vehicle, with more irritation than lower strengths | 16 |
This first double-blind study used the 0.1% strength; the 0.05% cream prescribed here is better tolerated with a slower onset.
NAMED SAFETY SIGNALS
What has been reported with Tretinoin 0.05%.
Contraindicated in pregnancy
The Retirides SmPC contraindicates the cream in pregnancy and in women planning or at risk of pregnancy; treatment is stopped if pregnancy occurs.
Retinoid dermatitis
Transient itching, warmth, mild redness, peeling similar to a mild sunburn, dryness and occasionally severe local erythema or oedema are described in the SmPC, most marked in the first weeks.
Photosensitivity
Sun sensitivity is increased; daily broad-spectrum sunscreen and avoidance of sunlamps are advised throughout treatment.
Not to be confused with oral tretinoin
Oral tretinoin is a hospital medicine for acute promyelocytic leukaemia. The evidence and safety profile above refer only to the topical cream.
FormTopical cream
FrequencyOnce a night
ResultsTexture by 3 months; lines at 6
StatusPrescription only
About
What is Tretinoin 0.05%?
Active ingredient: Tretinoin · Dosages: 0.05% cream
Tretinoin is the acid form of vitamin A and the reference prescription retinoid. In Spain the 0.05% cream (Retirides) is authorised for acne and as an adjunctive treatment for photoageing (fine wrinkles, mottled pigmentation, roughness); its use for fine lines, rough texture and sun-damage pigmentation is supported by randomised, vehicle-controlled trials of up to 2 years, and is prescribed at the doctor's discretion.
It is contraindicated in pregnancy and in women planning a pregnancy. A licensed doctor confirms this, checks for eczema or rosacea, and reviews at 3 months and 6 months.
How it works in the body
Tretinoin binds retinoic acid receptors in skin cells. Over months it thickens the living epidermis, normalises cell turnover, disperses pigment more evenly and increases collagen formation in the dermis, which is why fine lines and texture improve slowly rather than overnight.
How it helps
How it changes the skin over months.
Smoother texture
Normalised turnover evens out roughness within the first 3 months.
More even tone
Mottled pigmentation and lentigines fade with continued use.
Fine lines
Collagen formation increases slowly; changes in fine wrinkling are judged at 6 months.
What to expect
Start low, build to nightly.
Apply a pea-sized amount for the whole face at night, 20 to 30 minutes after washing, avoiding the eyelids, lip corners and nostrils. Follow with a moisturiser. SPF 50+ every morning is part of the treatment.
- Weeks 1-4 · Two or three nights a week; expect dryness and peeling
- Weeks 5-8 · Every other night as tolerated
- Months 3-6 · Nightly; texture improves first, lines are judged at 6 months
- Ongoing · Continue nightly or as advised; benefits need continued use
Doses your doctor can prescribe
- StandardTretinoin 0.05% cream, nightly
Your schedule is personal
These are typical steps only. Your doctor adjusts the plan to how you respond and tolerate it — and you can message them at any point.
Safety first
Safety, in full.
Tretinoin 0.05% is an effective medicine — and like any medicine it carries risks. Your doctor screens for all of this before prescribing. Here's the honest picture, not just reassurance.
Applied as a very thin layer at night, introduced gradually and paired with daily SPF 50+ protection.
- Use only as prescribed on the affected skin.
- Follow the treatment plan and review schedule your doctor gives you.
Who should not use it
- Pregnancy, trying to conceive, or a personal or family history of skin cancer.
- Active eczema, sunburn, broken skin or allergy to tretinoin or the cream ingredients.
When to seek urgent care
For severe, sudden or unexpected symptoms, call your local emergency number or go to the nearest emergency department. Then let your doctor know through your account chat.
PRICING
You only pay if treatment is approved.
€25/month for weight loss or €15/month (billed €45 every 90 days) for hair growth. €35 one-off is available for sexual health.
Weight loss
ONGOING PLAN
€25/month
Billed €25 every 28 days · cancel anytime
28-day treatment cycle
For ongoing treatment and doctor-reviewed renewals.
Renewals reviewed by your doctor
Start consultation
Full refund if a review is not approved
WHAT'S INCLUDED
- First consultation included
- Renewals reviewed by your doctor
- Ongoing care with your doctor
- Cancel anytime
Hair growth
ONGOING PLAN
€15/month
Billed €45 every 90 days · cancel anytime
For ongoing treatment and doctor-reviewed renewals.
Lowest monthly price we offer
Start consultation
Full refund if a review is not approved
WHAT'S INCLUDED
- First consultation included
- Renewals reviewed by your doctor
- Ongoing care with your doctor
- Cancel anytime
Sexual health
ONE-OFF
€35 one-off
One consultation, one doctor, one decision.
Nothing stored publicly, ever
Start consultation
Full refund if a review is not approved
WHAT'S INCLUDED
- Consultation reviewed by an EU-licensed doctor
- Electronic prescription if approved
- Full refund if not approved
Full refund if a review is not approved
For a one-off consultation, we refund the €35 consultation fee. For a subscription review, we refund that period's fee and cancel the plan.
Note: The medication, if the doctor prescribes it, is paid separately at the pharmacy at the price it sets. Hi-Doctor does not sell medications.
HOW THE DOCTOR DECIDES
A licensed doctor reviews your case, not an algorithm
An EU-licensed doctor reads your questionnaire and answers in less than 2 hours on average.
If the doctor decides it is not safe to prescribe, the consultation fee is refunded in full.
Follow-up happens in the private chat inside your account, under GDPR. No WhatsApp, no SMS.
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Find out if it's right for you
See if Tretinoin 0.05% is appropriate for you.
Answer a few questions and a licensed EU doctor reviews your case in less than 2 hours on average. Refunded in full if it's not right for you.