What is alprostadil and when is it used?

It is a prostaglandin E1 that directly dilates the penile vessels. It is considered when oral PDE5s are ineffective or contraindicated.

What precautions apply?

Correct administration technique, risk of local pain, priapism (prolonged erection) and, rarely, fibrosis. The doctor explains the protocol and warning signs.

Can it be combined with other ED treatments?

Combination with PDE5 is considered only under medical supervision. It is never paired without explicit indication due to priapism risk.

Can I get a consultation for Alprostadil from San Sebastián?

Yes. Hi-Doctor runs 100 % online across the EU, so if you live in San Sebastián you can fill in the questionnaire and receive the medical review without travelling. The electronic prescription issued by the licensed doctor is valid in any EU pharmacy under Directive 2011/24/EU; in Spain it is dispensed directly from the prescription QR.

Is my sexual health consultation fully confidential?

Yes. All communication happens in the private chat of your account, GDPR-compliant. The doctor treats discretion as a core of the service and there is no history visible outside your consultation.

What is the private electronic prescription and why is it valid across the EU?

The private electronic prescription (Receta Médica Privada Electrónica) is issued by a licensed doctor in Spain. It is a PDF carrying every field required by EU Directive 2011/24/EU (patient, prescriber with country of registration, active ingredient, dose), which makes it legally recognised across all 27 EU member states. In Spanish pharmacies it is dispensed from the QR; outside Spain, the pharmacist dispenses the locally marketed equivalent of the same active ingredient.

How does Hi-Doctor work step by step?

1) Fill in an online medical questionnaire in about 4 minutes. 2) The plan is €25 every 4 weeks for weight loss or €35 every 3 months for hair growth; sexual health is €35 per consultation. 3) An EU-licensed doctor reviews your case and, if appropriate, issues an electronic prescription. 4) Collect it at any EU pharmacy. If the review is not approved, the applicable fee is refunded in full.

How much does it cost and what does the price include?

The plan is €25 every 4 weeks for weight loss or €35 every 3 months for hair growth; a one-off sexual-health consultation is €35. Each includes a licensed doctor's review and an electronic prescription if approved. If the review is not approved, the applicable fee is refunded in full. Medication is paid for separately at the pharmacy at the price it sets.

Alprostadil · San SebastiánPrescription only

Online medical consultation for Alprostadil in San Sebastián.

An EU-licensed doctor reviews your case and, if eligible, issues an electronic prescription valid in any pharmacy in Spain. Consultation €35, refunded if the doctor decides it is not safe to prescribe.

A non-PDE5 route
Direct, local action
An option when oral PDE5s don't work or aren't allowed

€35 one-offFull refund if a review is not approved

Start consultation · €35 See how it works

Medication, if prescribed, is dispensed and paid for separately at a pharmacy.

FormUrethral cream or injection

FrequencyOn demand

ResultsDirect local action

StatusPrescription only

About

What is Alprostadil?

Active ingredient: Alprostadil · Dosages: Cream 3 mg/g on demand

Alprostadil is a prostaglandin E1 that directly dilates the blood vessels of the penis. It's considered when oral PDE5 inhibitors are ineffective or contraindicated.

It's administered as a urethral cream or an intracavernous injection, under medical instruction — each route has its own efficacy and tolerability profile. Correct technique matters, and the doctor explains the protocol and the warning signs.

How it works in the body

Rather than blocking an enzyme, alprostadil acts directly on the penile blood vessels, dilating them locally — no PDE5 pathway involved, so it can work where oral options don't.

How it helps

How it helps.

A different pathway

Works directly on the blood vessels — not through the PDE5 enzyme.

Local application

Applied where it acts, shortly before intercourse.

Guided by your doctor

Administration technique and warning signs are explained before you start.

What to expect

How to use it.

Prescribed with clear administration instructions. Your doctor explains the protocol, and follow-up happens through your account chat.

Prescribed with clear administration instructions
Applied shortly before intercourse
Correct technique matters — your doctor explains it
Follow-up and questions through your account chat

Forms your doctor can prescribe

Urethral cream3 mg/g — on demand
Pharmacy price~€90–140 / pack

Your schedule is personal

These are typical steps only. Your doctor adjusts the plan to how you respond and tolerate it — and you can message them at any point.

Safety first

Safety, in full.

Alprostadil is an effective medicine — and like any medicine it carries risks. Your doctor screens for all of this before prescribing. Here's the honest picture, not just reassurance.

Local pain or burning at the application site is the most frequent effect. Tolerability differs between the cream and injection routes.

Not suitable if you

Have been told you are at risk of priapism (prolonged erections)
Have an anatomical condition of the penis your doctor hasn't assessed
Would combine it with a PDE5 without explicit medical indication

When to seek urgent care

For severe, sudden or unexpected symptoms, call your local emergency number or go to the nearest emergency department. Then let your doctor know through your account chat.

PRICING

Two clear ways to continue your care.

€35 one-off. €25 / 4 weeks for weight loss or €11.67/mo (billed €35 every 3 months) for hair growth.

ONE-OFF

One-off consultation

€35

One consultation, one doctor, one decision.

Start consultation

WHAT'S INCLUDED

Consultation reviewed by an EU-licensed doctor
Electronic prescription if approved
Full refund if not approved

Full refund if a review is not approved For a one-off consultation, we refund the €35 consultation fee. For a subscription review, we refund that period's fee and cancel the plan.

Note: The medication, if the doctor prescribes it, is paid separately at the pharmacy at the price it sets. Hi-Doctor does not sell medications.

Reviews

What our patients say.

Verified reviews from Hi-Doctor patients · names changed for privacy · individual results vary.

Discreet from start to finish. The questionnaire was thorough and the doctor adjusted my dose after feedback.

Daniel P.

3 months in treatment

They checked my heart medication before prescribing — that level of care is why I stayed.

Sergio L.

7 months in treatment

Asking questions through the private chat was easy, and the answers came from the actual doctor.

Andreas W.

4 months in treatment

FREQUENTLY ASKED QUESTIONS

Questions about Alprostadil.

Find out if it's right for you

See if Alprostadil is appropriate for you.

Answer a few questions and a licensed EU doctor reviews your case within 24 hours. Refunded in full if it's not right for you.

Start consultation · €35 See Sexual health

OTHER SEXUAL HEALTH TREATMENTS

Explore related treatments.

Sildenafil Viagrasildenafil Tadalafil Cialistadalafil Vardenafil Levitravardenafil Avanafil Spedraavanafil Stendraavanafil Vitarosalprostadil Caverjectalprostadil MUSEalprostadil

ALSO AVAILABLE IN

The Alprostadil consultation works the same way across the EU.

MadridES BarcelonaES ValenciaES SevillaES ZaragozaES MálagaES BilbaoES Palma de MallorcaES AlicanteES MurciaES VigoES GranadaES

AVAILABLE ACROSS SPAIN