Can I get it?
Yes, if a doctor decides it is right for you. Avanafil 50/100/200mg is authorised in the EU and can be prescribed after a medical review.
An EU-licensed doctor reviews your case and, if eligible, issues an electronic prescription valid at any EU pharmacy under Directive 2011/24/EU.

Full refund if a review is not approved · Medication, if prescribed, is dispensed and paid for separately at a pharmacy.
IN PLAIN TERMS
Avanafil is a prescription tablet for erectile dysfunction, authorised across the EU since 2013 and the most recently approved of the tablets in this group. It works like the others by keeping the blood vessels in the penis relaxed so blood can flow in during sexual arousal. The EU product information says the usual 100 mg dose is taken about 15 to 30 minutes before sex. As with the rest of this group, it must never be taken with nitrate heart medicines.
Avanafil 50/100/200mg has been authorised for use in the EU since 21 June 2013, so a licensed doctor can prescribe it when it is clinically appropriate for you.
Yes, if a doctor decides it is right for you. Avanafil 50/100/200mg is authorised in the EU and can be prescribed after a medical review.
Our doctors review every Sexual health option and recommend what fits your history and goals.
See all Sexual health optionsEvery trial behind Avanafil 50/100/200mg is listed below with its registry number, how many people took part, and whether the results are peer-reviewed or a company announcement.
Jump to the studiesVERIFIED EVIDENCE
WHAT IT IS
Avanafil blocks the PDE5 enzyme that normally ends an erection, letting the blood vessels in the penis stay relaxed and fill with blood when a man is sexually aroused.
DEVELOPMENT STAGE
Every NCT identifier links to its ClinicalTrials.gov record. A readout is not the same as peer-reviewed publication.
| TRIAL / NCT | POPULATION | PARTICIPANTS | STATUS | READOUT / COMPLETION |
|---|---|---|---|---|
| TA-301 — randomised, double-blind, placebo-controlled Phase 3 trialNCT00790751 | Men with mild to severe generalised erectile dysfunction | 646 | Read out | 2012-04-01 |
| TA-302 — randomised, double-blind, placebo-controlled Phase 3 trialNCT00809471 | Men with type 1 or type 2 diabetes and erectile dysfunction | 390 | Read out | 2012-08-01 |
| EU registration programme — four randomised, double-blind, placebo-controlled trials of up to 3 months | General erectile dysfunction, diabetic erectile dysfunction, and erectile dysfunction after bilateral nerve-sparing radical prostatectomy | 1,774 | Read out | — |
Results are grouped by source and evidence grade so journal data and manufacturer announcements cannot be confused.
| DOSE OR GROUP | MEAN WEIGHT CHANGE | WEEKS |
|---|---|---|
| 50 / 100 / 200 mg | Mean change in SEP2 and SEP3 success rates and in IIEF erectile function domain score significantly favoured every dose over placebo (p<=0.001) | 12 |
| 50 / 100 / 200 mg | Of 300 attempts made within 15 minutes of dosing, 64% to 71% were successful vs 27% on placebo | 12 |
| 50 / 100 / 200 mg | Of 80 attempts made more than 6 hours after dosing, 59% to 83% were successful vs 25% on placebo | 12 |
The 15-minute and 6-hour figures come from small subsets of attempts (300 and 80 respectively) inside a 12-week trial, so they are much less precise than the overall 12-week results.
Last reviewed 2026-07-27
NAMED SAFETY SIGNALS
Listed as common in the EU product information — between 1 in 100 and 1 in 10 men — and named as one of the most frequently reported reactions across a safety database of 2,566 exposed subjects.
Listed as common in the EU product information — between 1 in 100 and 1 in 10 men.
Listed as common in the EU product information — between 1 in 100 and 1 in 10 men. Sinus congestion is listed as uncommon.
Listed as uncommon in the EU product information adverse-reaction table — between 1 in 1,000 and 1 in 100 men — although the safety summary names it among the most frequently reported reactions.
Both listed as uncommon in the EU product information — between 1 in 1,000 and 1 in 100 men.
Contraindicated with nitrate medicines and nitric-oxide donors, and in men with serious cardiovascular conditions such as recent heart attack, stroke or unstable angina.
IN 60 SECONDS
BRAND FACTS
Spedra is centrally authorised, so a single EU authorisation covers all 27 member states; it was granted on 21 June 2013 and is held by Menarini International Operations Luxembourg S.A. It is the EU brand for avanafil, the most recently authorised of the erectile-dysfunction tablets. Sexual stimulation is required for the medicine to work.
About
Spedra contains the active ingredient avanafil.
Active ingredient: Avanafil · Dosages: 50 / 100 / 200 mg on demand
Avanafil is the most recent PDE5 inhibitor, with fast onset (15–30 minutes) and a somewhat narrower side-effect profile in some studies. It's useful when timing flexibility matters.
It's prescribed at 50, 100 or 200 mg on demand, around 15–30 minutes before sexual activity. If there's no response, the doctor reassesses: dose adjustment, a switch to another PDE5, or evaluation of underlying causes — never a self-prescribed change.
HOW IT WORKS
Avanafil inhibits the PDE5 enzyme, improving penile blood flow in response to sexual stimulation. Its rapid absorption gives it one of the fastest onsets in the class.
Avanafil does nothing on its own. When you are sexually aroused, nerves and blood-vessel lining in the penis release a gas called nitric oxide. That release is the trigger for everything that follows, which is why the EU product information states that sexual stimulation is required for the tablet to work.
Nitric oxide switches on an enzyme that makes cyclic guanosine monophosphate, usually shortened to cGMP. cGMP is the chemical messenger that tells the smooth muscle inside the erectile tissue to relax. As that muscle relaxes, blood flows into the penis faster than it drains away, and an erection builds.
An enzyme called phosphodiesterase type 5, or PDE5, normally breaks cGMP down and ends the erection. Avanafil is described in the EU label as a highly selective, potent, reversible inhibitor of PDE5, so cGMP lasts longer and an erection is easier to reach and to keep.
How it helps
Can act in as little as 15–30 minutes.
The newest PDE5, with fewer vasomotor effects in some profiles.
The dose is tailored to your response and current medication.
What to expect
On demand, shortly before sexual activity. The doctor tailors the dose to your response and current medication.
Doses your doctor can prescribe
DAY TO DAY
Swallow one tablet by mouth roughly 15 to 30 minutes before sexual activity. That is the timing given in the EU product information for the usual 100 mg dose, and the same window applies to the 50 mg and 200 mg strengths.
The tablet does not cause an erection by itself. The label is explicit that sexual stimulation is needed for a response, because avanafil only extends a chemical signal that arousal starts in the first place.
The maximum recommended dosing frequency is once per day. Taking a second tablet because the first seemed not to work is outside the licence and raises the risk of low blood pressure, dizziness and fainting.
You can take avanafil with or without food. A high-fat meal delays the peak blood level by about 1.25 hours on average and lowers it by about 39%, so a heavy meal beforehand can push back the onset.
Grapefruit juice inhibits the CYP3A4 enzyme that clears avanafil, which would raise the amount in your blood. The label advises avoiding grapefruit juice in the 24 hours before a dose.
Alcohol combined with avanafil made the drop in diastolic blood pressure significantly larger than either alone in a crossover study. Drinking raises the chance of dizziness, light-headedness or fainting after a dose.
Tell the prescriber whether the dose worked, how it was tolerated and what else you take. Any change of strength, or a decision to stop, is theirs to make with you rather than something to try alone.
Safety first
Avanafil 50/100/200mg is an effective medicine — and like any medicine it carries risks. Your doctor screens for all of this before prescribing. Here's the honest picture, not just reassurance.
Stop and get urgent medical help if
seek medical help immediately
these need urgent attention, whatever the frequency
Common
common (≥1/100 to <1/10)
roughly between 1 in 100 and 1 in 10 people
Uncommon
uncommon (≥1/1,000 to <1/100)
roughly between 1 in 1,000 and 1 in 100 people
Rare
rare (≥1/10,000 to <1/1,000)
roughly between 1 in 10,000 and 1 in 1,000 people
Erectile dysfunction in adult men.
WHO SHOULD NOT TAKE IT, AND WHO NEEDS EXTRA CARE
| MEDICINE OR SUBSTANCE | WHAT CAN HAPPEN | WHAT THE DOCTOR DOES |
|---|---|---|
| Nitrates and nitric oxide donors (e.g. GTN spray, amyl nitrite) | Avanafil amplifies the blood-pressure-lowering effect of nitrates, which can become dangerous. | Absolute contraindication; the prescriber will not issue avanafil alongside nitrates. |
| Riociguat and other guanylate cyclase stimulators | Additive lowering of systemic blood pressure with no demonstrated clinical benefit. | Absolute contraindication; the prescriber chooses a different route for erectile dysfunction. |
| Potent CYP3A4 inhibitors (ketoconazole, ritonavir and similar) | Ketoconazole raised avanafil exposure about 14-fold and lengthened its half-life to roughly 9 hours. | Absolute contraindication; the prescriber checks every current medicine before issuing. |
| Moderate CYP3A4 inhibitors (erythromycin, diltiazem, verapamil, fluconazole) | Erythromycin roughly tripled avanafil exposure and lengthened its half-life to about 8 hours. | Caps the dose at 100 mg and no more than once every 48 hours. |
| Alpha-blockers (doxazosin, tamsulosin) | Additive widening of blood vessels can cause symptomatic low blood pressure in some men. | Starts avanafil at 50 mg, and only once you are stable on the alpha-blocker. |
| Other blood-pressure-lowering medicines (e.g. amlodipine, enalapril) | Small additive falls in blood pressure; amlodipine also raised avanafil exposure by about 60%. | Monitors blood pressure and warns you about dizziness on standing. |
| CYP3A4 inducers (rifampicin, carbamazepine, phenobarbital, efavirenz, bosentan) | May clear avanafil faster and reduce how well it works; this has not been studied. | Concomitant use is not recommended, so the prescriber reviews alternatives. |
| Grapefruit juice and alcohol | Grapefruit juice raises avanafil levels; alcohol deepens the fall in diastolic blood pressure. | Advises no grapefruit juice for 24 hours beforehand and caution with alcohol. |
EVIDENCE
Avanafil's EU licence rests on four randomised, double-blind, placebo-controlled trials in 1,774 men, the programme reported by Goldstein and colleagues in 2012.
General population of men with erectile dysfunction
Placebo was about 28%. The 50 mg dose gave about 47% and 200 mg about 59%.
Source: Spedra: EU Product Information (Summary of Product Characteristics and package leaflet)Men with erectile dysfunction · Single dose, measured at about 15 minutes
Time-to-onset study using the SEP3 measure. Placebo was 13.78% and the 200 mg dose gave 28.18%.
Source: Spedra: EU Product Information (Summary of Product Characteristics and package leaflet)Men with type 1 or type 2 diabetes and erectile dysfunction
Placebo was about 21%, and 100 mg gave about 34%.
Source: Spedra: EU Product Information (Summary of Product Characteristics and package leaflet)Men with erectile dysfunction after bilateral nerve-sparing radical prostatectomy
Placebo was about 9%.
Source: Spedra: EU Product Information (Summary of Product Characteristics and package leaflet)These figures are averages across groups of men in trials, not a forecast for any one person. A placebo tablet also worked some of the time, so the gap between avanafil and placebo is the meaningful part rather than the raw percentage. Results varied sharply by underlying cause, with much lower success rates after prostate surgery than in the general group, and an individual response can sit anywhere around these averages.
ALTERNATIVES
| MEDICINE | HOW IT IS TAKEN | HOW OFTEN | TYPICAL DOSE RANGE | EU-AUTHORISED INDICATION | KEY EVIDENCE |
|---|---|---|---|---|---|
| Sildenafil | Tablet by mouth | As needed, up to once daily | 25 to 100 mg | Treatment of men with erectile dysfunction; sexual stimulation is required. | EAU-cited trials: 56 to 84% reported improved erections |
| Tadalafil | Tablet by mouth | As needed, or 5 mg once daily | 2.5 to 20 mg | Treatment of erectile dysfunction, and of the signs and symptoms of benign prostatic hyperplasia in adult men. | EAU-cited trials: 67 to 81% reported improved erections |
| Vardenafil | Tablet by mouth | As needed, up to once daily | 5 to 20 mg | Treatment of erectile dysfunction in adult men; sexual stimulation is required. | EAU-cited trials: 66 to 80% reported improved erections |
Not sure which one fits your case? The doctor reviews your history and tells you.
Start consultation · €35ACCESS AND COST
Avanafil is prescription-only across the EU, so no pharmacy in any member state can supply it without a valid prescription. Who pays varies: the rows below record what each national medicines register or national formulary states, and say so plainly where the official source does not publish a reimbursement position.
What you pay Hi-Doctor
€35 one-off
Answer a few questions and a licensed EU doctor reviews your case in less than 2 hours on average. Refunded in full if it's not right for you.
What the pharmacy charges
Hi-Doctor does not sell, stock or dispense medicines and does not set their price. The medicine is paid for separately at the pharmacy, and the amount depends on the country, the pack size, whether a generic is available and whether your health system covers it. The official national database linked in the table publishes the current authorised price.
| COUNTRY | HOW IT IS SUPPLIED | COVERED BY THE HEALTH SYSTEM? | OFFICIAL SOURCE |
|---|---|---|---|
| Spain | Prescription-only | Not stated by the national register | AEMPS CIMA |
| Germany | Prescription-only | Classed as a lifestyle preparation | PharmNet.Bund AMIce |
|---|---|---|---|
| France | Prescription-only | Not reimbursed | Base de données publique des médicaments |
| Italy | Prescription-only | Restricted — see national criteria | AIFA Medicinali |
| Netherlands | Prescription-only | Not in the GVS reimbursement system | CBG-MEB Geneesmiddeleninformatiebank |
| Portugal | Prescription-only | Not stated by the national register | INFARMED Infomed |
| Belgium | Prescription-only | Not stated by the national register | FAGG-AFMPS medicines database |
| Ireland | Prescription-only | Not stated by the national register | HPRA Find a Medicine |
| Austria | Prescription-only | Not stated by the national register | BASG Medikamente Info Austria |
| Poland | Prescription-only | Not stated by the national register | Rejestr Produktów Leczniczych |
PRICING
€35 for one sexual-health consultation. Paid once, with no recurring charge.
ONE-OFF
€35 one-off
One consultation, one doctor, one decision.
Nothing stored publicly, ever
Full refund if a review is not approved
WHAT'S INCLUDED
Full refund if a review is not approved
If a review is not approved, we refund the €35 consultation fee in full.
Note: The medication, if the doctor prescribes it, is paid separately at the pharmacy at the price it sets. Hi-Doctor does not sell medications.
HOW THE DOCTOR DECIDES
An EU-licensed doctor reads your questionnaire and answers in less than 2 hours on average.
If the doctor decides it is not safe to prescribe, the consultation fee is refunded in full.
Follow-up happens in the private chat inside your account, under GDPR. No WhatsApp, no SMS.
FREQUENTLY ASKED QUESTIONS
OTHER SEXUAL HEALTH TREATMENTS
SOURCES
Spedra (avanafil): EPAR medicine overview — European Medicines Agency, 2026
Spedra: EU Product Information (Summary of Product Characteristics and package leaflet) — European Medicines Agency, 2026
Spedra 100 mg tablets: Summary of Product Characteristics — electronic medicines compendium (Datapharm), 2026
A randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of avanafil in subjects with erectile dysfunction — The Journal of Sexual Medicine 9(4):1122-33, 2012
EAU Guidelines on Sexual and Reproductive Health: Management of Erectile Dysfunction — European Association of Urology, 2026
Viagra (sildenafil): EPAR medicine overview — European Medicines Agency, 2026
Cialis (tadalafil): EPAR medicine overview — European Medicines Agency, 2026
Levitra (vardenafil): EPAR medicine overview — European Medicines Agency, 2025
CIMA: Spedra 50/100/200 mg comprimidos, authorised and marketed, prescription-only — AEMPS (Spanish Agency for Medicines and Medical Devices), 2026
Avanafil, human medicines with a currently valid German authorisation: 28 entries, Spedra 50, 100 and 200 mg tablets (Menarini International Operations Luxembourg S.A., EU/1/13/841) and parallel-distributed packs, all prescription-only — BfArM AMIce, public part, via PharmNet.Bund, Germany, 2026
§ 34 Abs. 1 SGB V: medicines used predominantly to improve sexual potency are excluded from statutory health insurance — Bundesministerium der Justiz, Germany, 2026
Base de données publique des médicaments: SPEDRA 50/100/200 mg, autorisation active, commercialisée, no reimbursement rate listed — ANSM / Ministère de la Santé (France), 2026
Banca Dati Farmaci: Spedra (avanafil), packs in classe C a totale carico dell'assistito and classe A with a therapeutic plan — AIFA (Italian Medicines Agency), 2026
Farmacotherapeutisch Kompas: avanafil (Spedra, Menarini Benelux), marked XGVS, not included in the GVS reimbursement system — Zorginstituut Nederland, 2026
INFOMED: Spedra (avanafil) 50/100/200 mg, Autorizado, at least one presentation marketed — INFARMED (Portuguese National Authority of Medicines), 2026
Geneesmiddelendatabank: Spedra 200 mg tabl., EU/1/13/841, availability recorded per pack, medisch voorschrift — FAGG / AFMPS (Belgian Federal Agency for Medicines and Health Products), 2026
Human Medicines authorised list: Spedra 50/100/200 mg tablets, registration status AU, supply through pharmacies only — HPRA (Health Products Regulatory Authority, Ireland), 2026
Medikamente Info Austria: Spedra 50/100/200 mg Tabletten, no discontinuation of marketing reported, repeat prescription, pharmacy supply — BASG (Austrian Federal Office for Safety in Health Care), 2026
Rejestr Produktów Leczniczych: Spedra (Avanafilum) 50/100/200 mg tabletki, centralised procedure, ATC G04BE10 — Ministry of Health / e-Zdrowie (Poland), 2026
Reviewed by Hi-Doctor's medical team · Last reviewed 2026-07-27 · Next review due 2027-07-27
This page is educational information about a medicine, not a recommendation to take it and not a substitute for a medical consultation. Only a licensed doctor who has reviewed your history can decide whether a treatment is appropriate for you.
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