Can I get it?
Yes, if a doctor decides it is right for you. Compounded melasma formula is prepared to prescription by a compounding pharmacy after a medical review; allow a few days for it to be made.
Compounded melasma formula · SloveniaPrescription only
Online medical consultation for Compounded melasma formula in Slovenia.
An EU-licensed doctor reviews your case and, if eligible, issues an electronic prescription valid in any pharmacy in Slovenia. Consultation €35, refunded if the doctor decides it is not safe to prescribe.
- Prepared to prescription by a compounding pharmacy
- Kligman-type formula: retinoid boosts hydroquinone's effect
- Two nights a week for 3 months, with SPF 50+ daily
Start consultationStart consultation · €35
Full refund if a review is not approved · Medication, if prescribed, is dispensed and paid for separately at a pharmacy.
IN PLAIN TERMS
What Compounded melasma formula is, and how to get treatment
Compounded melasma formula is used in weight management. Whether it suits you depends on your medical history, your other medicines and your goals — which is exactly what a consultation is for.
Compounded melasma formula is a magistral preparation: its components are authorised medicines in the EU, and a compounding pharmacy combines them to a licensed doctor's prescription. The combination itself is not a licensed product.
What can I take instead?
Our doctors review every Dermatology option and recommend what fits your history and goals.
See all Dermatology optionsWhat do the studies show?
Every trial behind Compounded melasma formula is listed below with how many people took part and whether the results are peer-reviewed or a company announcement.
Jump to the studiesLocal consultation facts
Can I get Compounded melasma formula in Slovenia?
Yes. Residents of Slovenia can request an online doctor consultation about Compounded melasma formula with Hi-Doctor. A licensed EU doctor reviews the case and issues a prescription only when clinically appropriate. If approved, the EU prescription arrives as a PDF for a pharmacist in Slovenia, who dispenses the locally marketed equivalent containing Melasma-combination-formula.
Availability
Compounded melasma formula is available to residents of Slovenia through the online consultation. A prescription follows only if the doctor approves it.
- Country
- Slovenia
- Language of service
- Spanish and English
- Prescription turnaround
- In less than 4 hours on average, only if the doctor approves
- Honoured locally
- PDF honoured locally for an equivalent containing Melasma-combination-formula
How the EU prescription works where you are: In Slovenia, show the approved prescription PDF to a pharmacist. They honour it under EU cross-border rules and dispense the locally marketed equivalent containing Melasma-combination-formula.
VERIFIED EVIDENCE
Compounded melasma formula: evidence and regulatory guide.
WHAT IT IS
How it works
A Kligman-type compounded cream in which low-strength tretinoin increases the penetration and effect of hydroquinone, with kojic acid and niacinamide adding tyrosinase inhibition and barrier support.
- retinoic acid receptor (RAR)
DEVELOPMENT STAGE
Pharmacy-compounded preparation
Trial register3 registered trials
Every NCT identifier links to its ClinicalTrials.gov record. A readout is not the same as peer-reviewed publication.
| TRIAL / NCT | POPULATION | PARTICIPANTS | STATUS | READOUT / COMPLETION |
|---|---|---|---|---|
| Kligman and Willis 1975 (hydroquinone + tretinoin + dexamethasone formula) | Adults with melasma and other hyperpigmentation, open-label | — | Read out | 1975 |
| Taylor 2003 (fixed triple combination vs dual combinations) | Adults with moderate to severe facial melasma, nightly for 8 weeks, two randomised investigator-blind studies | — | Read out | 2003 |
| Chan 2008 (fixed triple combination vs hydroquinone 4%) | Asian adults with moderate to severe melasma, 8 weeks | — | Read out | 2008 |
What the studies reported
Results are grouped by source and evidence grade so journal data and manufacturer announcements cannot be confused.
Peer-reviewed
Taylor SC et al. Cutis 2003;72(1):67-72| DOSE OR GROUP | MEAN WEIGHT CHANGE | WEEKS |
|---|---|---|
| Hydroquinone 4% + tretinoin 0.05% + fluocinolone 0.01%, nightly | 77% reached a melasma severity score of none or mild | 8 |
| Dual combinations (any two of the three) | Lower response than the triple combination | 8 |
The trial product contained a corticosteroid and tretinoin 0.05% used nightly. Our compounded formula uses tretinoin 0.025% with kojic acid and niacinamide instead of a corticosteroid, applied twice a week. The combination has not been studied in that form; component evidence is cited.
Peer-reviewed
Navarrete-Solís J et al. Dermatol Res Pract 2011;2011:379173| DOSE OR GROUP | MEAN WEIGHT CHANGE | WEEKS |
|---|---|---|
| Niacinamide 4% cream | 44% good to excellent improvement; fewer side effects than hydroquinone | 8 |
Small split-face study of 27 patients supporting niacinamide as a component, not as a replacement for hydroquinone.
NAMED SAFETY SIGNALS
What has been reported with Compounded melasma formula.
Contraindicated in pregnancy
Tretinoin is contraindicated in pregnancy and in women planning a pregnancy, and hydroquinone is not recommended. Both components are avoided in breastfeeding.
Irritation and post-inflammatory darkening
Redness and peeling from tretinoin can, if severe, trigger new pigmentation in melasma-prone skin. This is why the formula is applied only twice a week and stopped for persistent inflammation.
Ochronosis with prolonged hydroquinone
Courses are limited to 3 months with a planned break, and total continuous hydroquinone exposure never exceeds 6 months.
Compounded product
Prepared to prescription by a pharmacy under national magistral rules; stability and shelf life follow the pharmacy's label rather than an EU marketing authorisation.
FormCompounded cream
FrequencyTwo nights a week
ResultsGradual, judged at 8-12 weeks
StatusPrescription only
About
What is Compounded melasma formula?
Active ingredient: Melasma-combination-formula · Dosages: Hydroquinone 4% + tretinoin 0.025% + kojic acid 2% + niacinamide 4%
The melasma formula is a magistral night cream combining hydroquinone 4%, tretinoin 0.025%, kojic acid 2% and niacinamide 4%. It follows the principle described by Kligman and Willis in 1975, in which a retinoid increases the penetration and effect of hydroquinone, replacing the original corticosteroid with kojic acid and niacinamide.
Because it is stronger than hydroquinone alone, it is used only two nights a week and only on the patches. A licensed doctor confirms that the pigmentation is melasma, excludes pregnancy, and reviews photographs at 2 months. The combination itself is compounded rather than a licensed product.
How it works in the body
Hydroquinone and kojic acid both inhibit tyrosinase, reducing new melanin from two angles. Tretinoin speeds cell turnover so pigmented cells shed faster and hydroquinone penetrates better. Niacinamide slows the transfer of pigment from melanocytes to skin cells and supports the barrier.
How it helps
Four actives, one night cream.
Two tyrosinase inhibitors
Hydroquinone and kojic acid reduce the production of new pigment.
Faster turnover
Low-strength tretinoin sheds pigmented cells and improves penetration.
Barrier support
Niacinamide reduces pigment transfer and helps the skin tolerate the actives.
What to expect
Two nights a week, three months.
Apply a thin layer to the patches only, two non-consecutive nights a week, on fully dry skin after cleansing. Wash off in the morning and apply SPF 50+. Never increase the frequency without your doctor's advice.
- Weeks 1-2 · Two nights a week; redness and peeling are expected
- Weeks 3-6 · Skin adapts; patches begin to fade
- Week 8 · Photo review with your doctor
- Month 3 · Complete the course, then a planned break with SPF only
Formula your doctor can prescribe
- Standard formulaHydroquinone 4% + tretinoin 0.025% + kojic acid 2% + niacinamide 4%, 30 g
Your schedule is personal
These are typical steps only. Your doctor adjusts the plan to how you respond and tolerate it — and you can message them at any point.
Safety first
Safety, in full.
Compounded melasma formula is an effective medicine — and like any medicine it carries risks. Your doctor screens for all of this before prescribing. Here's the honest picture, not just reassurance.
Redness, peeling, dryness and stinging are expected in the first weeks, from the tretinoin and hydroquinone components. Lightening of the surrounding skin can occur if the cream spreads beyond the patch.
Not suitable if you
- Are pregnant, planning a pregnancy or breastfeeding
- Are allergic to hydroquinone, tretinoin, kojic acid, niacinamide or any excipient
- Have eczema, rosacea flares, sunburn or broken skin in the treatment area
- Cannot commit to daily broad-spectrum sun protection during and after the course
When to seek urgent care
For severe, sudden or unexpected symptoms, call your local emergency number or go to the nearest emergency department. Then let your doctor know through your account chat.
PRICING
You only pay if treatment is approved.
€25/month for weight loss or €15/month (billed €45 every 90 days) for hair growth. €35 one-off is available for sexual health.
Weight loss
ONGOING PLAN
€25/month
Billed €25 every 28 days · cancel anytime
28-day treatment cycle
For ongoing treatment and doctor-reviewed renewals.
Renewals reviewed by your doctor
Start consultation
Full refund if a review is not approved
WHAT'S INCLUDED
- First consultation included
- Renewals reviewed by your doctor
- Ongoing care with your doctor
- Cancel anytime
Hair growth
ONGOING PLAN
€15/month
Billed €45 every 90 days · cancel anytime
For ongoing treatment and doctor-reviewed renewals.
Lowest monthly price we offer
Start consultation
Full refund if a review is not approved
WHAT'S INCLUDED
- First consultation included
- Renewals reviewed by your doctor
- Ongoing care with your doctor
- Cancel anytime
Sexual health
ONE-OFF
€35 one-off
One consultation, one doctor, one decision.
Nothing stored publicly, ever
Start consultation
Full refund if a review is not approved
WHAT'S INCLUDED
- Consultation reviewed by an EU-licensed doctor
- Electronic prescription if approved
- Full refund if not approved
Full refund if a review is not approved
For a one-off consultation, we refund the €35 consultation fee. For a subscription review, we refund that period's fee and cancel the plan.
Note: The medication, if the doctor prescribes it, is paid separately at the pharmacy at the price it sets. Hi-Doctor does not sell medications.
HOW THE DOCTOR DECIDES
A licensed doctor reviews your case, not an algorithm
An EU-licensed doctor reads your questionnaire and answers in less than 2 hours on average.
If the doctor decides it is not safe to prescribe, the consultation fee is refunded in full.
Follow-up happens in the private chat inside your account, under GDPR. No WhatsApp, no SMS.
FREQUENTLY ASKED QUESTIONS
Questions about Compounded melasma formula.
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Find out if it's right for you
See if Compounded melasma formula is appropriate for you.
Answer a few questions and a licensed EU doctor reviews your case in less than 2 hours on average. Refunded in full if it's not right for you.