Dapoxetine (Priligy)

Dapoxetine is the only medication specifically developed and approved for the treatment of premature ejaculation (PE). Unlike other SSRIs used off-label, dapoxetine is a short-acting serotonin reuptake inhibitor designed to be taken on-demand 1-3 hours before sexual activity, without the need for daily dosing.

Clinical trials show dapoxetine increases intravaginal ejaculatory latency time (IELT) by 3-4 times, with significant improvements in ejaculatory control, sexual satisfaction, and reduced distress. At hi-doctor.ai, our doctors provide confidential PE consultations and prescriptions.

Dapoxetine rapidly inhibits serotonin reuptake, increasing serotonin levels in the synaptic cleft. This enhances inhibitory control over the ejaculatory reflex. Its short half-life (~1.5h) means effects are temporary, avoiding the continuous SSRI exposure of daily antidepressants.

Common: nausea, headache, dizziness, diarrhea. Usually mild and dose-dependent. Avoid alcohol. Not for patients on other serotonergic medications.