TREATMENT GUIDE
Rybelsus (oral semaglutide) treatment guide
Everything you need to know about your Rybelsus treatment — how to take it, your dose schedule, managing side effects, and when to contact your doctor.
How to use
Step 1
Take on an empty stomach
Take Rybelsus first thing in the morning, at least 8 hours after your last meal. Swallow the tablet whole with a sip of water (no more than 120 ml). Do not split, crush, or chew the tablet.
Step 2
Wait 30 minutes before eating
After taking the tablet, wait at least 30 minutes before eating or drinking anything (including other medications). This is important for the medication to be absorbed properly.
Step 3
Take it at the same time each day
Consistency helps maintain steady levels. If you miss a dose, skip it and take the next one at the usual time. Do not take two doses at once.
Dose schedule
First 30 days: 1.5 mg once daily
Starting dose. Your body is adjusting to the medication.
From day 31: 4 mg once daily
Increased dose. Remain at this level for at least 30 days.
Maintenance: 9 mg once daily
Full maintenance dose for ongoing treatment. Your doctor will reassess every 3 months.
Side effects
Nausea
Very common in the first weeks. Eat smaller meals, avoid fatty or fried foods, and eat slowly. Nausea usually improves within 1-2 weeks.
Constipation or diarrhoea
Drink plenty of water (6-8 glasses a day). Include fibre-rich foods like vegetables and whole grains. Gentle movement like walking can help.
Fatigue
Some patients feel tired in the first weeks. This usually passes. Rest when needed and keep your meals light.
When to seek help
Contact your doctor if you have severe abdominal pain that does not go away, persistent vomiting, signs of an allergic reaction (rash, itching, swelling), or any symptom that worries you.
When to contact your doctor
- Severe or persistent nausea, vomiting, or diarrhoea that prevents you from eating or drinking
- Severe abdominal pain that does not go away
- Signs of an allergic reaction (rash, itching, swelling of the face or throat)
- Any symptom that worries you or feels unusual
Storage
Store at room temperature below 25°C. Keep in the original packaging to protect from light and moisture. Do not use after the expiry date on the carton.
What to expect
Rybelsus works similarly to injectable semaglutide but is taken as a daily tablet. Appetite changes may begin in 2-4 weeks. Weight loss is assessed at 3 months. Your doctor will review your progress quarterly.
Talk to a doctor about your treatment.
A licensed EU doctor reviews your case and, if appropriate, issues a prescription in under 24 hours.
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