TREATMENT GUIDE
Mounjaro (tirzepatide) treatment guide
Everything you need to know about your Mounjaro treatment — how to inject, your dose schedule, managing side effects, and when to contact your doctor.
How to use
Step 1
Choose your injection site
Rotate between abdomen, thigh, or upper arm each week. Clean the area with an alcohol swab and let it dry.
Step 2
Inject at the same time each week
Pick a day that works for you. If you forget a dose, take it within 4 days of the missed dose. If more than 4 days have passed, skip that dose and take your next one on the regular scheduled day.
Step 3
Use a new needle each time
Remove the needle after each injection and dispose of it safely in a sharps container. Never reuse needles.
Step 4
Subcutaneous injection
Mounjaro is injected just under the skin (subcutaneous). Do not inject into a vein or muscle. Use the abdomen, thigh, or upper arm. The injection pen delivers the full dose — hold it in place for 5 seconds after the click.
Dose schedule
Weeks 1-4: 2.5 mg once weekly
This is the starting dose to help your body adjust. Do not increase during this period.
Weeks 5-8: 5 mg once weekly
Your first step-up dose. Continue at this level for 4 weeks.
Weeks 9-12: 7.5 mg once weekly
Second step-up. Your doctor may adjust this schedule based on how you are responding.
Weeks 13-16: 10 mg once weekly
Continue to build up to your maintenance dose.
Weeks 17-20: 12.5 mg once weekly
Penultimate step. Your doctor will assess your progress.
Week 21+: 15 mg once weekly (maintenance)
Maximum dose. Stay at this level for ongoing treatment. Your doctor will reassess every 3 months.
Side effects
Nausea
Very common in the first weeks. Eat smaller meals, avoid fatty or fried foods, and eat slowly. Nausea usually improves within 1-2 weeks.
Constipation or diarrhoea
Drink plenty of water (6-8 glasses a day). Include fibre-rich foods like vegetables and whole grains. Gentle movement like walking can help.
Fatigue
Some patients feel tired in the first weeks. This usually passes. Rest when needed and keep your meals light.
When to seek help
Contact your doctor if you have severe abdominal pain that does not go away, persistent vomiting, signs of an allergic reaction (rash, itching, swelling), or any symptom that worries you.
When to contact your doctor
- Severe or persistent nausea, vomiting, or diarrhoea that prevents you from eating or drinking
- Severe abdominal pain that does not go away
- Signs of an allergic reaction (rash, itching, swelling of the face or throat)
- Any symptom that worries you or feels unusual
Storage
Store unused pens in the refrigerator (2-8°C). Once opened, keep at room temperature below 30°C for up to 30 days. Do not freeze. Keep away from direct heat and light.
What to expect
Most patients notice reduced appetite within 2-4 weeks. Clinically meaningful weight loss is assessed at 3 months. A loss of 5% or more of your starting weight at 3 months is considered a good response. Your doctor will review your progress quarterly.
Talk to a doctor about your treatment.
A licensed EU doctor reviews your case and, if appropriate, issues a prescription in under 24 hours.
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