Can I get it?
Not for this use. Contrave has no EU authorisation for it, so it cannot be prescribed or dispensed here for that purpose.
Why buying it online is risky
Contrave · Split
Contrave in Split: what you should know.
NOT AVAILABLE IN THE EUContrave has no EU marketing authorisation for this use.
We don't prescribe it today, but our doctors can review your case and propose an equivalent weight management treatment with EU approval and clinical evidence.
€25/month (billed €25 every 28 days)Full refund if a review is not approved
IN PLAIN TERMS
What Contrave is, and how to get treatment
Contrave is the United States brand name for a weight-management tablet that combines naltrexone and bupropion. There is no medicine called Contrave on sale in the European Union. The identical combination is authorised in the EU under a different brand name, Mysimba, so the medicine itself is available to EU patients on prescription, just not under the name Contrave. If you have read about Contrave online, you are reading about the American product, and any website offering to ship Contrave to an EU address is not operating within EU medicines law.
Contrave has no EU marketing authorisation for this use. It may be an approved medicine for something else, or approved in another country — but not something a doctor here can prescribe for this.
What can I take instead?
Orlistat 120mg is approved in the EU, has published peer-reviewed trial results, and can be prescribed today if a doctor decides it suits you.
Read about Orlistat 120mgWhat do the studies show?
Every trial behind Contrave is listed below with its registry number, how many people took part, and whether the results are peer-reviewed or a company announcement.
Jump to the studiesLocal consultation facts
Can I get Contrave in Split?
Not through Hi-Doctor. Hi-Doctor does not prescribe Contrave. People in Split, Croatia, can request an online consultation for Weight loss with a licensed EU doctor, who may recommend an available option when clinically appropriate. If approved, the EU prescription arrives as a PDF for a pharmacist in Croatia, who dispenses the locally marketed equivalent with the prescribed active ingredient.
Availability
Hi-Doctor does not prescribe Contrave. The links below show options in Weight loss that our doctors can assess.
- Country
- Croatia
- Language of service
- Spanish and English
- Prescription turnaround
- In less than 4 hours on average, only if the doctor approves
- Honoured locally
- PDF honoured locally for the prescribed active ingredient
How the EU prescription works where you are: In Croatia, show the approved prescription PDF to a pharmacist. They honour it under EU cross-border rules and dispense the locally marketed equivalent with the prescribed active ingredient.
TREATMENT OPTIONS
Available medical weight-management options
A licensed doctor decides case by case. We never prescribe without evaluation.
Rx · GLP-1
Prescription only
Semaglutide (Wegovy / Ozempic)
Weekly GLP-1 receptor agonist. A doctor may prescribe it if your BMI and history match the indications. Requires follow-up.
Weekly injection pen
€25/month
Rx · GLP-1 / GIP
Prescription only
Tirzepatide (Mounjaro)
Dual GLP-1/GIP agonist. Assessed by the doctor based on comorbidities and the patient's BMI.
Weekly injection pen
€25/month
Rx · GLP-1
Prescription only
Liraglutide (Saxenda)
Daily GLP-1 agonist. Indicated in selected patients with elevated BMI after medical evaluation.
Daily injection pen
€25/month
Rx · lipase inhibitor
Prescription only
Orlistat 120mg
Fat-absorption inhibitor. A non-GLP-1 alternative a doctor may consider based on your history.
Capsules
€25/month
Rx · oral GLP-1
Prescription only
Rybelsus (oral semaglutide)
A once-daily semaglutide tablet authorised for type 2 diabetes. Any use in weight management is an individual medical decision and may be off-label.
Daily tablets
€25/month
You pay for any medication separately at the pharmacy you choose. Hi-Doctor does not sell medications.
WHAT IT COSTS
One plan, reviewed by a doctor.
Weight loss
ONGOING PLAN
€25/month
Billed €25 every 28 days · cancel anytime
28-day treatment cycle
For ongoing treatment and doctor-reviewed renewals.
Renewals reviewed by your doctor
Start consultation
Full refund if a review is not approved
WHAT'S INCLUDED
- First consultation included
- Renewals reviewed by your doctor
- Ongoing care with your doctor
- Cancel anytime
Full refund if a review is not approved
If a review is not approved, we refund that period's €25 fee and cancel the plan.
Note: The medication, if the doctor prescribes it, is paid separately at the pharmacy at the price it sets. Hi-Doctor does not sell medications.
VERIFIED EVIDENCE
Contrave: evidence and regulatory guide.
WHAT IT IS
How it works
A tablet combining two older medicines, naltrexone and bupropion, which together act on the parts of the brain that control hunger and food cravings.
- Mu-opioid receptor (blocked by naltrexone)
- Dopamine transporter
- Noradrenaline transporter
DEVELOPMENT STAGE
Not marketed in the EU
Trial register1 registered trials
Every NCT identifier links to its ClinicalTrials.gov record. A readout is not the same as peer-reviewed publication.
| TRIAL / NCT | POPULATION | PARTICIPANTS | STATUS | READOUT / COMPLETION |
|---|---|---|---|---|
| COR-INCT00532779 | Adults with obesity, or overweight with high blood pressure or abnormal blood fats, without type 2 diabetes | 1,742 | Read out | 2010-08-21 |
What the studies reported
Results are grouped by source and evidence grade so journal data and manufacturer announcements cannot be confused.
Peer-reviewed
Greenway FL, Fujioka K, Plodkowski RA, et al. Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2010;376(9741):595-605. doi:10.1016/S0140-6736(10)60888-4| DOSE OR GROUP | MEAN WEIGHT CHANGE | WEEKS |
|---|---|---|
| Naltrexone 32 mg + bupropion 360 mg daily (NB32) | −6.1% body weight (−6.0 kg) | 56 |
| Placebo | −1.3% body weight (−1.3 kg) | 56 |
| Naltrexone 32 mg + bupropion 360 mg daily (NB32) — responders | 48.0% lost at least 5% of body weight, versus 16.4% on placebo | 56 |
All participants also followed a reduced-calorie diet and exercise programme, and a large proportion of people randomised did not complete the 56 weeks, which makes the average figures harder to interpret.
Sources
Last reviewed 2026-07-27
NAMED SAFETY SIGNALS
What has been reported with Contrave.
Nausea
Reported by 31.8% of people taking naltrexone/bupropion in the pooled clinical trials, versus 6.7% on placebo.
Constipation
Reported by 18.1% of people taking naltrexone/bupropion, versus 7.2% on placebo.
Vomiting
Reported by 9.9% of people taking naltrexone/bupropion, versus 2.9% on placebo.
Seizures
Occurred in approximately 0.06% of trial participants taking naltrexone/bupropion (2 of 3,239), versus none of 1,515 on placebo. The combination must not be used by anyone with a current or past seizure disorder.
Stopping treatment because of side effects
23.8% of people taking naltrexone/bupropion stopped because of an adverse reaction, versus 11.9% on placebo.
Cannot be combined with opioids
Naltrexone blocks opioid receptors, so the combination is contraindicated in people who are dependent on opioids or going through opioid withdrawal.
UNAPPROVED PRODUCTS ONLINE
Why buying Contrave online is not a shortcut.
No doctor in the EU can prescribe it for this use — including ours. It may be authorised in another country, or for a different condition.
Check the EU common logo
A legitimate online pharmacy in the EU must display the common logo linked to its national register. The logo is a verification check; it cannot make an unapproved medicine legal.
How the EU common logo worksFREQUENTLY ASKED QUESTIONS
Questions about Contrave.
OTHER WEIGHT LOSS TREATMENTS