Orlistat

Orlistat is a weight loss medication that works by blocking the absorption of approximately 30% of dietary fat in the intestines. Available in prescription strength (120mg) and lower over-the-counter doses, orlistat provides a non-hormonal approach to weight management that can be used long-term.

Orlistat is particularly suitable for patients who prefer a non-injectable option or who are not candidates for GLP-1 medications. Average weight loss is 5-7% of body weight over 12 months when combined with a reduced-calorie diet.

Orlistat inhibits pancreatic and gastric lipase, enzymes that break down dietary fat. The undigested fat passes through the GI tract and is excreted, reducing overall caloric absorption.

GI effects are common and diet-dependent: oily/fatty stools, increased frequency, flatulence. These effects are minimized by following a low-fat diet (≤30% calories from fat).