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MEDICATION SAFETY

Semaglutide safety summary

  • INN
  • semaglutide
  • GLP-1 receptor agonist
  • once-weekly subcutaneous injection
  • brand: Wegovy

Semaglutide is a GLP-1 receptor agonist that works in the brain's appetite centres and slows stomach emptying, so you feel fuller for longer and eat less. It is prescribed for chronic weight management alongside a reduced-calorie diet and increased physical activity.

Adults with obesity (BMI ≥30) or with overweight (BMI ≥27) plus at least one weight-related condition such as type 2 diabetes, hypertension or dyslipidaemia.

  • Once-weekly self-injection in the thigh, abdomen or upper arm.
  • Dose is escalated gradually (0.25 mg → 0.5 → 1.0 → 1.7 → 2.4 mg) over 16 weeks to limit gastrointestinal side effects.
  • Combined with diet and physical activity — semaglutide is not a substitute for lifestyle change.

  • Severe abdominal pain radiating to the back (possible pancreatitis) — stop the medicine and seek urgent care.
  • Gallbladder problems — sudden right-upper abdominal pain, jaundice, fever.
  • Sudden vision changes in patients with type 2 diabetic retinopathy — see an ophthalmologist promptly.
  • Signs of severe dehydration from prolonged vomiting / diarrhoea — risk of acute kidney injury.
  • Severe allergic reaction (rash, swelling, breathlessness).

WHEN TO CALL THE DOCTOR

Call us through the in-app chat if you notice…

  • Severe or persistent vomiting, dehydration, or inability to eat for more than 48h.
  • New, severe abdominal pain that doesn't ease — A&E first.
  • Pregnancy or a positive pregnancy test — stop the medicine immediately.
  • A new medication or condition since your last consultation.

OFFICIAL SOURCE

This summary is condensed from the regulator's full product leaflet for ease of reading. The complete document — every interaction, dose adjustment and reporting note — is one click away.

EMA — Wegovy product information

This page summarises information from the regulator-approved leaflet for reference only. It is not medical advice and does not replace the assessment of an EU-licensed doctor. Your doctor will review your individual history, dose and interactions during your consultation.

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