Dutasteride 0.5mg in Estland, online
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Dutasteride 0.5mg-Beratungen in Estland
Was es ist und wie es wirkt
Dutasteride inhibits both isoforms of 5-alpha-reductase (I and II), while finasteride only acts on type II. The DHT blockade is more complete, which can translate into a better response in some patients.
It's typically considered when finasteride hasn't given a sufficient response after 6–12 months, or when the pattern of loss is particularly aggressive. It's off-label for alopecia in some countries, so the doctor weighs it case by case.
Für wen es ist
- Authorised in the EU for an enlarged prostate; hair-loss use is off-label.
- One 0.5 mg capsule swallowed whole once a day, with or without food.
Sicherheit im Überblick
Sexual side effects are common and may continue after you stop the capsules.
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Ihre Fragen, beantwortet
Worin unterscheidet sich Dutasterid von Finasterid?
Wann verschreibt ein Arzt Dutasterid?
Weitere Fragen
Welche Nebenwirkungen hat Dutasterid?
Kann ich von Finasterid auf Dutasterid wechseln?
Ist Dutasterid bei Haarausfall besser als Finasterid?
Wie lange bleibt Dutasterid im Körper?
Kann ein Arzt in Europa Dutasterid gegen Haarausfall verschreiben?
Was sollte ich tun, wenn unter Dutasteride 0.5mg Nebenwirkungen auftreten?
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Arzneimittelinformationen und Sicherheit
Wie wirkt Dutasteride 0.5mg?
DHT shrinks scalp hair follicles. Testosterone is turned into a stronger hormone, dihydrotestosterone or DHT, by an enzyme called 5-alpha-reductase. In men with male pattern hair loss, the balding scalp carries miniaturised follicles and higher amounts of DHT, so each follicle grows a thinner, shorter hair.
Dutasteride blocks both enzyme types. Dutasteride inhibits both the type 1 and the type 2 forms of 5-alpha-reductase. Finasteride inhibits only the type 2 form. Blocking both routes means less testosterone is converted overall, which is why blood DHT falls further on dutasteride than on a type 2 blocker alone.
Less DHT reaches the follicle. With less DHT circulating, the shrinking process slows and some follicles can go back to producing thicker hair. In men treated for an enlarged prostate, which is the EU-authorised use, median blood DHT fell by 94 percent at one year. Any scalp effect builds over months.
Anwendung von Dutasteride 0.5mg
Get a prescriber's decision first. Dutasteride is prescription-only everywhere in the EU. Because using it for hair loss is off-label here, a doctor has to weigh the benefits and risks with you, and can decide it is not appropriate.
Swallow one capsule whole daily. The dose is one 0.5 mg soft capsule by mouth once a day. Swallow it whole. Do not chew it or open it, because contact with the contents can irritate the mouth and throat.
Take it with or without food. Food does not change how much dutasteride your body absorbs, so choose a time you will remember and keep to it. Blood levels reach about 90 percent of steady state after three months.
Keep capsules away from others. Dutasteride passes through skin. Women who are or could become pregnant, children and adolescents must not handle leaking capsules. If contact happens, wash the area straight away with soap and water.
Use a condom if needed. Small amounts of dutasteride reach semen. If your partner is pregnant or might become pregnant, the label advises using a condom, because the medicine can affect how a male foetus develops.
Do not donate blood. Do not give blood until at least six months have passed since your last dose. The wait exists so that dutasteride in donated blood cannot reach a pregnant woman receiving a transfusion.
Flag it before a PSA test. Dutasteride roughly halves the PSA blood test used to look for prostate cancer, within three to six months. Tell any doctor who orders a PSA that you take it, so the result is read correctly.
Give it several months. For the licensed prostate use the label says a response can take up to six months. In the hair-loss trial the main result was measured at week 24, so judge it slowly and with your prescriber.
Häufige Nebenwirkungen
Stop and get urgent medical help if (seek medical help immediately): Swelling of the face, lips, tongue or throat, or difficulty breathing, Sudden widespread rash, hives or intense itching after a dose, A new breast lump, breast pain, or discharge from a nipple, Breathlessness, unusual tiredness, or swelling of the ankles and legs, Thoughts of harming yourself, or a low mood that will not lift, Pain and swelling in a testicle that does not settle
Most people who get side effects get these (common (≥1/100 to <1/10)): Trouble getting or keeping an erection, reported by 6.0 percent in year one, Lower sex drive, reported by 3.7 percent in year one, Difficulty ejaculating, including less semen, reported by 1.8 percent in year one, Breast enlargement or tenderness, reported by 1.3 percent in both years, Sexual side effects that may continue after you stop the medicine, Dizziness, mainly when dutasteride is taken together with tamsulosin
Less common, or frequency not known (uncommon (≥1/1,000 to <1/100)): Loss of body hair, or unwanted extra hair growth elsewhere, Heart failure, reported mainly when dutasteride is combined with tamsulosin, Depression and low mood, reported after marketing, frequency not known, Pain and swelling in the testicles, frequency not known, Allergic reactions with rash, itching, hives or swelling, frequency not known, Reduced sperm count, semen volume and sperm motility in healthy men, Male breast cancer, reported rarely in trials and after marketing
Nehmen Sie Dutasteride 0.5mg nicht ein, wenn
- You are a woman, a child or an adolescent
- You are pregnant, could become pregnant, or are breastfeeding
- You have ever reacted badly to dutasteride or another 5-alpha-reductase inhibitor such as finasteride
- You are allergic to soya or peanut, because the capsule contains lecithin that may contain soya oil
- You have severe liver impairment
- You plan to donate blood within the next six months
- You and your partner are trying to conceive, since dutasteride can reduce sperm count and motility
- You have not had the prostate examination and PSA test the label requires before starting
- You cannot swallow a capsule whole, because it must never be chewed or opened
Arzneimittel und Substanzen mit Wechselwirkungen
- Strong CYP3A4 blockers (ritonavir, indinavir, nefazodone, itraconazole, oral ketoconazole): Can raise dutasteride blood levels, and the already long half-life may be prolonged further. Prescriber may reduce how often you take dutasteride if side effects appear.
- Verapamil or diltiazem (heart and blood-pressure medicines): Dutasteride levels averaged 1.6 to 1.8 times higher in patients also taking these. Prescriber notes the higher exposure and reviews you if side effects appear.
- Alpha-blockers such as tamsulosin: The combination raised ejaculation problems and dizziness, and cardiac failure was marginally higher. Prescriber combines them only after a careful benefit and risk assessment.
- PSA blood test for prostate cancer: Dutasteride lowers mean PSA by about 50 percent, so older results no longer compare. Prescriber sets a new PSA baseline at six months and tracks changes from it.
- Warfarin and digoxin: Dutasteride had no effect on how the body handles either medicine in studies. No dose change needed, though the prescriber still reviews your full medicine list.
- Colestyramine (cholesterol-lowering powder): 12 g taken one hour after a dutasteride dose did not change its levels. No change to dose or timing is needed on the basis of this study.
Quellen
- Avodart 0.5 mg soft capsules (dutasteride): Summary of Product Characteristics electronic medicines compendium (emc), GlaxoSmithKline UK, 2024
- Avodart 0.5 mg soft capsules: Package Leaflet, Information for the patient electronic medicines compendium (emc), GlaxoSmithKline UK, 2024
- Dutasteride capsules: full FDA prescribing information (blood donation, half-life, PSA) DailyMed, US National Library of Medicine, 2024
- NCT01231607: dutasteride versus placebo and finasteride in men with androgenetic alopecia, posted results ClinicalTrials.gov, US National Library of Medicine, 2014
- Gubelin Harcha W et al. A randomized, active- and placebo-controlled study of different doses of dutasteride versus placebo and finasteride in male androgenetic alopecia Journal of the American Academy of Dermatology (via PubMed), 2014
- Olsen EA et al. The importance of dual 5-alpha-reductase inhibition in the treatment of male pattern hair loss Journal of the American Academy of Dermatology (via PubMed), 2006
- Article 31 referral: finasteride and dutasteride containing medicinal products, measures to minimise the risk of suicidal thoughts European Medicines Agency, 2025
- List of nationally authorised medicinal products, active substances dutasteride and dutasteride/tamsulosin (PSUSA/00010506/201711) European Medicines Agency, 2018
- Report on the Deliberation Results, Zagallo Capsules 0.1 mg and 0.5 mg (dutasteride), indication androgenetic alopecia in men Pharmaceuticals and Medical Devices Agency, Japan (Ministry of Health, Labour and Welfare), 2015
- Long-term effectiveness and safety of dutasteride versus finasteride in male androgenetic alopecia in South Korea: a multicentre chart review Annals of Dermatology, 2023
- AEMPS CIMA: dutasterida 0,5 mg cápsulas blandas, authorised and marketed products, prescription status Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), 2026
- Base de données publique des médicaments: dutasteride 0,5 mg capsule molle, reimbursement restricted to benign prostatic hyperplasia ANSM / Ministère de la Santé, France, 2026
- Dutasterid, human medicines with a currently valid German authorisation: 46 entries, Avodart 0,5 mg soft capsules and its generics, all prescription-only BfArM AMIce, public part, via PharmNet.Bund, Germany, 2026
- Propecia 1 mg film-coated tablets (finasteride): Summary of Product Characteristics electronic medicines compendium (emc), Organon, 2025
- Regaine for Men Extra Strength Scalp Solution 5% w/v (minoxidil): Summary of Product Characteristics electronic medicines compendium (emc), Johnson & Johnson, 2024
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