Posso ottenerlo?
Sì, se un medico ritiene che sia adatto a Lei. Tirzepatide è autorizzato nell’UE e può essere prescritto dopo una valutazione medica.
Un medico autorizzato dall'UE esamina il Suo caso e, se idoneo, rilascia una prescrizione elettronica valida in qualsiasi farmacia dell'UE ai sensi della direttiva 2011/24/UE.

Rimborso completo se una valutazione non viene approvata · Il farmaco, se prescritto, viene dispensato e pagato separatamente in farmacia.
IN PAROLE SEMPLICI
Tirzepatide è un medicinale somministrato con un’iniezione sotto la pelle una volta alla settimana. Agisce contemporaneamente su due segnali ormonali naturali dell’intestino, GLP-1 e GIP. Insieme riducono l’appetito e rallentano il passaggio del cibo dallo stomaco, quindi di solito le persone mangiano meno. Nell’UE viene venduta come Mounjaro. È stata autorizzata per la prima volta nel settembre 2022 per il diabete di tipo 2 e la sua autorizzazione è stata estesa l’11 dicembre 2023 al controllo del peso insieme a una dieta con meno calorie e più attività fisica.
Tirzepatide è autorizzato per l’uso nell’UE dal 11 dicembre 2023. Un medico abilitato può quindi prescriverlo quando è clinicamente adatto a Lei.
Maggiori informazioni sui peptidi su Peptidepedia.
Sì, se un medico ritiene che sia adatto a Lei. Tirzepatide è autorizzato nell’UE e può essere prescritto dopo una valutazione medica.
I nostri medici esaminano ogni opzione per Perdita di peso e consigliano quella più adatta alla Sua storia clinica e ai Suoi obiettivi.
Veda tutte le opzioni per Perdita di pesoTutti gli studi su Tirzepatide sono elencati qui sotto con il numero di registro, il numero di partecipanti e l’indicazione se i risultati sono stati sottoposti a revisione paritaria o provengono da un annuncio dell’azienda.
Vada agli studiEVIDENZE VERIFICATE
CHE COS’È
It switches on two gut-hormone receptors at the same time, GIP and GLP-1, which together reduce appetite and slow how quickly the stomach empties.
FASE DI SVILUPPO
Ogni identificativo NCT rimanda al record ClinicalTrials.gov. Una comunicazione dei risultati non equivale a una pubblicazione sottoposta a revisione paritaria.
| STUDIO / NCT | POPOLAZIONE | PARTECIPANTI | STATO | RISULTATO / COMPLETAMENTO |
|---|---|---|---|---|
| SURMOUNT-1NCT04184622 | Adults with a BMI of 30 kg/m² or more, or 27 kg/m² or more with at least one weight-related complication, without type 2 diabetes; all received diet and exercise counselling | 2,539 | Con risultati | 2022-07-21 |
I risultati sono separati per fonte e grado di evidenza, così i dati scientifici non vengono confusi con gli annunci del produttore.
| DOSE O GRUPPO | VARIAZIONE MEDIA DEL PESO | SETTIMANE |
|---|---|---|
| 5 mg once weekly | −15.0% | 72 |
| 10 mg once weekly | −19.5% | 72 |
| 15 mg once weekly | −20.9% | 72 |
| Placebo | −3.1% | 72 |
Figures are the treatment-regimen estimand at week 72; people with type 2 diabetes were excluded, everyone also received diet and exercise counselling, and the trial did not follow weight after treatment stopped.
Ultima revisione 2026-07-27
SEGNALI DI SICUREZZA IDENTIFICATI
In SURMOUNT-1, reported by 24.6% (5 mg), 33.3% (10 mg) and 31.0% (15 mg) versus 9.5% on placebo.
In SURMOUNT-1, reported by 18.7% (5 mg), 21.2% (10 mg) and 23.0% (15 mg) versus 7.3% on placebo.
In SURMOUNT-1, reported by 16.8% (5 mg), 17.1% (10 mg) and 11.7% (15 mg) versus 5.8% on placebo.
In SURMOUNT-1, reported by 8.3% (5 mg), 10.7% (10 mg) and 12.2% (15 mg) versus 1.7% on placebo.
Alopecia was reported by 5.1% (5 mg), 4.9% (10 mg) and 5.7% (15 mg) versus 0.9% on placebo in SURMOUNT-1.
Independently confirmed in 3 people on tirzepatide and 1 on placebo across the SURMOUNT-1 safety dataset reviewed by the EMA.
4.3% (5 mg), 7.1% (10 mg) and 6.2% (15 mg) stopped treatment because of side effects versus 2.6% on placebo.
IN 60 SECONDI
Sul trattamento
Commercializzato anche come Mounjaro, Zepbound.
Principio attivo: Tirzepatide · Dosaggi: 2.5 – 15 mg / week
Tirzepatide is a dual receptor agonist — it acts on the GLP-1 and GIP gut-hormone receptors at the same time. In clinical trials this translates into larger average weight loss than mono-agonist GLP-1s in adults with obesity.
It's a chronic treatment for as long as it's beneficial and safe: the doctor reviews your response every 3 months and decides with you whether to continue, adjust or stop. Discontinuation is gradual and paired with a maintenance plan.
COME AGISCE
By activating two receptors at once, tirzepatide reinforces satiety signals, slows stomach emptying and helps regulate the insulin response — so you tend to eat less without counting every calorie.
Tirzepatide activates the receptors for two natural gut hormones, GIP and GLP-1, which the body releases after eating. The EU product information describes it as a long acting GIP and GLP-1 receptor agonist that binds both receptors with high affinity.
Both of those receptors also sit in the brain areas that regulate appetite. Clinical studies cited in the product information report that tirzepatide reduces energy intake and appetite by increasing feelings of satiety and fullness, and by decreasing feelings of hunger.
Tirzepatide delays gastric emptying, so food leaves the stomach more slowly after a meal. It also increases insulin release in a glucose dependent way and lowers glucagon. The weight change comes mainly from eating less, and is mostly a loss of fat mass.
Come aiuta
Works on two gut-hormone receptors (GLP-1 + GIP), not just one.
Hunger eases and fullness lasts longer after smaller meals.
Your doctor reassesses response and tolerance every 3 months before renewing.
Cosa aspettarsi
The dose is escalated step-wise (2.5 → 5 → 7.5 → 10 → 12.5 → 15 mg) every 4 weeks while the body adapts. Your doctor sets your exact schedule.
Typical escalation
NELLA VITA QUOTIDIANA
Tirzepatide is injected once a week, at any time of day, with or without food. Pick a day that is easy to remember. You can change the day later as long as three days separate two doses.
Unused pens are kept in a refrigerator between 2 and 8 degrees Celsius, in the original carton so light cannot reach them, and must never be frozen. A pen that has been frozen must not be used.
Look at the liquid before you inject. It should be clear and free of particles or discolouration. Discard the pen if you can see anything floating in it, if it looks discoloured, or if it is out of date.
Tirzepatide goes under the skin of the abdomen, the thigh or the upper arm. The back of the upper arm needs another person to do the injection. Read the instructions for use packed with the pen first.
Injection sites should be rotated with each dose, so the same patch of skin is not used week after week. If you also inject insulin, use a different site for each of the two medicines.
If you remember within four days, inject then and return to your usual schedule. If more than four days have passed, skip that dose and take the next one on the normal day. Never inject two doses to catch up.
Single-dose pens and vials may be kept out of the refrigerator for up to 21 cumulative days below 30 degrees Celsius, then discarded. A multi-dose KwikPen holds four weekly doses and is thrown away 30 days after first use.
Tirzepatide is licensed as an addition to a reduced-calorie diet and increased physical activity, not as a replacement for them. Every trial result quoted on this page comes from people doing both alongside the weekly injection.
Sicurezza prima di tutto
Tirzepatide è un farmaco efficace — e, come ogni farmaco, comporta dei rischi. Il medico verifica tutto questo prima di prescrivere. Ecco il quadro onesto, non solo una rassicurazione.
Stop and get urgent medical help if
seek medical help immediately
these need urgent attention, whatever the frequency
Very common
very common (≥1/10)
more than 1 in 10 people
Common
common (≥1/100 to <1/10)
between 1 in 100 and 1 in 10 people
Uncommon
uncommon (≥1/1,000 to <1/100)
between 1 in 1,000 and 1 in 100 people
Rare
rare (≥1/10,000 to <1/1,000)
between 1 in 10,000 and 1 in 1,000 people
Adulti con obesità (BMI ≥30) o con sovrappeso (BMI ≥27) più almeno una condizione correlata al peso.
CHI NON DEVE ASSUMERLO E CHI RICHIEDE CAUTELA
| FARMACO O SOSTANZA | COSA PUÒ ACCADERE | COSA FA IL MEDICO |
|---|---|---|
| Oral medicines in general | Tirzepatide delays gastric emptying, so tablets can be absorbed more slowly, especially at the start. | Most oral medicines need no dose change. The prescriber reviews your full list. |
| Warfarin, digoxin and other narrow therapeutic index drugs | Absorption can shift when tirzepatide is started or the dose is increased. | The prescriber monitors you more closely at initiation and after each dose increase. |
| Sulfonylureas (for example gliclazide) | Combined use raises the risk of low blood sugar in people with type 2 diabetes. | The prescriber may reduce the sulfonylurea dose and ask for blood glucose self-monitoring. |
| Insulin | Combined use raises hypoglycaemia risk; clinically significant lows occurred in 14 to 19 percent. | The prescriber reduces insulin stepwise and arranges blood glucose self-monitoring. |
| Combined oral contraceptives | A single 5 mg dose reduced ethinylestradiol peak level by 59 percent and delayed it four hours. | EU labelling requires no dose change. UK labelling advises adding a barrier method for four weeks. |
| Paracetamol | A single 5 mg dose halved the paracetamol peak level and delayed it by one hour. | No dose adjustment needed. Overall exposure was unchanged after four consecutive weekly doses. |
| Oral medicines where rapid onset matters | Delayed gastric emptying can postpone the effect of a tablet you need to work quickly. | The prescriber considers timing, a non-oral route, or an alternative medicine. |
EVIDENZE
The SURMOUNT phase 3 programme tested tirzepatide against placebo for weight management, and reported mean body-weight reductions of 15.0% to 20.9% over 72 weeks depending on the dose.
2,539 adults with obesity or overweight, without diabetes · 72 weeks
SURMOUNT-1. Mean baseline weight 104.8 kg. The placebo group changed -3.1%.
Fonte: SURMOUNT-1: Tirzepatide once weekly for the treatment of obesity2,539 adults with obesity or overweight, without diabetes · 72 weeks
SURMOUNT-1. 3% of the placebo group reached that threshold. On 15 mg, 91% reached at least 5%.
Fonte: SURMOUNT-1: Tirzepatide once weekly for the treatment of obesity938 adults with obesity and type 2 diabetes · 72 weeks
SURMOUNT-2. This group sits inside the EU weight-management licence. The placebo group changed -3.2%.
Fonte: SURMOUNT-2: Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes670 adults who completed a 36-week tirzepatide lead-in · 52 weeks, from week 36 to week 88
SURMOUNT-4. Those switched to placebo regained weight over the following year.
Fonte: SURMOUNT-4: Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity670 adults who completed a 36-week tirzepatide lead-in · 88 weeks from baseline
SURMOUNT-4. The group switched to placebo at week 36 finished at -9.9% from baseline instead.
Fonte: SURMOUNT-4: Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesityThese figures are group averages from randomised trials, not a prediction for any one person. Some participants lost far more than the average and some lost very little, and everyone in these trials was also following a reduced-calorie diet and increased physical activity alongside the injection. SURMOUNT-4 also shows the effect depends on continuing treatment, because weight came back in the group that was switched to placebo.
ALTERNATIVE
| FARMACO | COME SI ASSUME | OGNI QUANTO | INTERVALLO DI DOSE ABITUALE | INDICAZIONE AUTORIZZATA NELL'UE | EVIDENZA PRINCIPALE |
|---|---|---|---|---|---|
| Semaglutide | Iniezione settimanale | Una volta a settimana | 0.25–2.4 mg | Adjunct to a reduced-calorie diet and increased physical activity for weight management in adults with BMI ≥30, or ≥27 to <30 with at least one weight-related comorbidity. | STEP 1: mean -14.9% body weight at 68 weeks versus -2.4% placebo |
| Liraglutide | Iniezione quotidiana | Una volta al giorno | 0.6–3.0 mg | Adjunct to a reduced-calorie diet and increased physical activity for weight management in adults with BMI ≥30, or ≥27 to <30 with at least one weight-related comorbidity. | SCALE: mean 8.4 kg lost at 56 weeks versus 2.8 kg on placebo |
| Orlistat | Capsula orale | Con ogni pasto principale | 120 mg per main meal | In conjunction with a mildly hypocaloric diet, for obese patients with BMI ≥30, or overweight patients with BMI ≥28 and associated risk factors. | XENDOS: mean 5.8 kg lost at four years versus 3.0 kg on placebo |
Non sai quale sia adatto al tuo caso? Il medico esamina la tua storia clinica e te lo dice.
Inizia consulto · 25 €/meseACCESSO E COSTI
Tirzepatide is a prescription-only medicine everywhere in the EU, so no pharmacy can supply it without a valid prescription from a doctor. Who pays varies by country, and in most of them weight management is not covered by the national health system, which means the patient pays the pharmacy directly. The entries for Spain, France, the Netherlands, Portugal, Belgium and Ireland come from the national sources listed below; the rows for Germany, Italy, Austria and Poland record the general position for this indication and are not confirmed against a national decision, so treat the register linked on those rows as the authority.
Quanto paghi a Hi-Doctor
25 €/mese (fatturati 25 € ogni 28 giorni)
Risponda ad alcune domande e un medico autorizzato dall'UE esaminerà il Suo caso in meno di 2 ore in media. Rimborso completo se non fa per Lei.
Quanto addebita la farmacia
Hi-Doctor non vende, non detiene e non dispensa farmaci e non ne stabilisce il prezzo. Il farmaco si paga separatamente in farmacia e l'importo dipende dal paese, dalla confezione, dalla disponibilità di un generico e dalla rimborsabilità. La banca dati ufficiale collegata nella tabella pubblica il prezzo autorizzato in vigore.
| PAESE | REGIME DI FORNITURA | RIMBORSATO DAL SISTEMA SANITARIO? | FONTE UFFICIALE |
|---|---|---|---|
| Spagna | Medicinale soggetto a prescrizione medica | Not reimbursed for weight management | AEMPS CIMA |
| Germania | Medicinale soggetto a prescrizione medica | Not reimbursed for weight management | PharmNet.Bund AMIce |
|---|---|---|---|
| Francia | Medicinale soggetto a prescrizione medica, con prescrizione iniziale da parte di uno specialista | Restricted, see national criteria | Base de données publique des médicaments |
| Italia | Medicinale soggetto a prescrizione medica | Not reimbursed for weight management | AIFA Medicinali |
| Paesi Bassi | Medicinale soggetto a prescrizione medica | Not reimbursed for weight management | CBG-MEB Geneesmiddeleninformatiebank |
| Portogallo | Medicinale soggetto a prescrizione medica | Not reimbursed for weight management | INFARMED Infomed |
| Belgio | Medicinale soggetto a prescrizione medica | Not reimbursed for weight management | FAGG-AFMPS medicines database |
| Irlanda | Medicinale soggetto a prescrizione medica | Not reimbursed by the HSE for weight loss | HPRA Find a Medicine |
| Austria | Medicinale soggetto a prescrizione medica | Not reimbursed for weight management | BASG Medikamente Info Austria |
| Polonia | Medicinale soggetto a prescrizione medica | Not reimbursed, patient pays in full | Rejestr Produktów Leczniczych |
PREZZI
25 €/mese per il controllo del peso o 15 €/mese (fatturati 45 € ogni 90 giorni) per la crescita dei capelli. Per la salute sessuale è disponibile una consultazione una tantum da 35 €.
PIANO CONTINUATIVO
25 €/mese
Fatturati 25 € ogni 28 giorni · annulli quando vuoi
Ciclo di trattamento di 28 giorni
Per un trattamento continuativo e rinnovi valutati dal Suo medico.
Rinnovi valutati dal Suo medico
Rimborso completo se una valutazione non viene approvata
COSA È INCLUSO
Rimborso completo se una valutazione non viene approvata
Se una valutazione non viene approvata, rimborsiamo la quota di 25 € di quel periodo e annulliamo il piano.
Nota: Il farmaco, se prescritto dal medico, viene pagato separatamente in farmacia al prezzo stabilito. Hi-Doctor non vende farmaci.
COME DECIDE IL MEDICO
Un medico abilitato nell'UE legge il tuo questionario e risponde in meno di 2 ore in media.
Se il medico decide che non è sicuro prescrivere, il costo della consulenza viene rimborsato per intero.
Il follow-up avviene nella chat privata del tuo account, nel rispetto del GDPR. Niente WhatsApp, niente SMS.
DOMANDE FREQUENTI
ALTRI TRATTAMENTI PERDITA DI PESO
FONTI
Mounjaro (tirzepatide): European public assessment report, medicine overview — European Medicines Agency, 2022
Mounjaro: Annex I Summary of Product Characteristics — European Commission Union Register of Medicinal Products, 2024
Mounjaro KwikPen 5 mg solution for injection in pre-filled pen: Summary of Product Characteristics — electronic medicines compendium (emc), 2026
Mounjaro KwikPen 15 mg solution for injection in pre-filled pen: Summary of Product Characteristics — electronic medicines compendium (emc), 2026
Mounjaro KwikPen 5 mg: Patient Information Leaflet — electronic medicines compendium (emc), 2026
Tirzepatide (Mounjaro): NHS medicines A to Z — NHS, 2026
SURMOUNT-1: Tirzepatide once weekly for the treatment of obesity — New England Journal of Medicine, 2022
SURMOUNT-2: Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes — The Lancet, 2023
SURMOUNT-4: Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity — JAMA, 2024
STEP 1: Once-weekly semaglutide in adults with overweight or obesity — New England Journal of Medicine, 2021
SCALE Obesity and Prediabetes: a randomized, controlled trial of 3.0 mg of liraglutide in weight management — New England Journal of Medicine, 2015
XENDOS: XENical in the prevention of Diabetes in Obese Subjects, a 4-year randomised study — Diabetes Care, 2004
Wegovy 2.4 mg FlexTouch solution for injection: Summary of Product Characteristics — electronic medicines compendium (emc), 2026
Saxenda 6 mg/mL solution for injection: Summary of Product Characteristics — electronic medicines compendium (emc), 2026
Xenical 120 mg hard capsules: Summary of Product Characteristics — electronic medicines compendium (emc), 2026
CIMA: Mounjaro presentations, marketing and prescription status in Spain — AEMPS (Spanish Agency of Medicines and Medical Devices), 2026
MOUNJARO (tirzépatide), obésité: avis de la Commission de la Transparence — Haute Autorité de Santé, 2025
Obésité: prise en charge de WEGOVY et MOUNJARO à partir du 15 juin 2026, sous conditions — VIDAL, reporting the arrêté published in the Journal officiel, 2026
Tirzepatide (Mounjaro): monograph and reimbursement status in Belgium — BCFI / CBIP, Belgian Centre for Pharmacotherapeutic Information, 2024
Find a Medicine: authorised medicines database — Health Products Regulatory Authority (Ireland), 2026
Medicijnkosten.nl: medicine reimbursement database — Zorginstituut Nederland, 2026
INFOMED: base de dados de medicamentos de uso humano — INFARMED (Portugal), 2026
Revisionato dal team medico di Hi-Doctor · Ultima revisione 2026-07-27 · Prossima revisione prevista il 2027-07-27
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