Understanding Set Point Theory and Weight Loss Resistance
Struggling with weight loss despite your best efforts? Learn how your body's 'set point' and weight loss resistance might be holding you back.

Understanding Set Point Theory and Weight Loss Resistance
Are you struggling with weight loss, feeling like your body is fighting against you every step of the way? You're not alone. Many people experience what's known as weight loss resistance, often linked to your body's 'set point' theory. The good news is that EU-licensed doctors can help. Through Hi-Doctor, you can access an online consultation for just €25, and if appropriate, receive a prescription for effective weight management medication in under 24 hours. This prescription is valid at any pharmacy across the EU.
How it works — get your weight management medication prescription in 4 steps
- Fill out a brief online medical questionnaire (takes 2–3 minutes) and securely pay the €25 consultation fee.
- A licensed EU doctor privately reviews your case. If the doctor determines the treatment is NOT appropriate, your €25 fee is **refunded automatically** — there's no risk to you.
- If approved, you receive a REMPE electronic prescription (a downloadable PDF file) in your Hi-Doctor account and by email within 24 hours.
- Print the PDF or show it on your phone — present it at **any pharmacy in the EU** to collect your medication.
Who qualifies for weight management medication
Our EU-licensed doctors carefully assess each patient to ensure treatment is safe and effective. They look at several factors, similar to what they would consider in a clinic visit:
- Body Mass Index (BMI): For medications like Wegovy (semaglutide) or Mounjaro (tirzepatide), you typically need a BMI of 30 or higher (obesity), or a BMI of 27 or higher (overweight) with at least one weight-related comorbidity such as high blood pressure, type 2 diabetes, or high cholesterol.
- Medical History: The doctor reviews your full medical history, including any existing conditions, allergies, and current medications, to identify potential contraindications or interactions.
- Previous Weight Loss Efforts: They will consider your past attempts at weight loss through diet and exercise, as these medications are intended to be used in conjunction with lifestyle changes.
- Absence of Contraindications: Certain conditions, such as a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), severe gastrointestinal disease, or pregnancy/breastfeeding, may make these medications unsuitable.
The doctor's priority is always your safety and well-being. They will only issue a prescription if they find it medically appropriate for your individual case.
What weight management medication actually does (and doesn't do)
Medications like Wegovy (semaglutide) and Mounjaro (tirzepatide) are GLP-1 receptor agonists. They work by mimicking a natural hormone in your body that regulates appetite and food intake. Here's what they do:
- Reduce Appetite: They help you feel fuller for longer, reducing overall calorie intake.
- Slow Gastric Emptying: Food stays in your stomach longer, contributing to prolonged fullness.
- Improve Blood Sugar Control: This can be particularly beneficial for patients with or at risk of type 2 diabetes.
These medications are powerful tools, but they are not magic pills. They work best when combined with a healthy diet and regular physical activity. You should expect gradual weight loss over several months, not overnight. They do not replace the need for lifestyle changes, but rather support them by making it easier to adhere to a reduced-calorie diet.
Side effects and when to stop
Like all medications, weight management treatments can have side effects. Common side effects often include:
- Nausea
- Diarrhea or constipation
- Vomiting
- Abdominal pain
These side effects are usually mild and tend to decrease over time as your body adjusts to the medication. However, it's crucial to be aware of more serious, though rare, side effects, such as pancreatitis or gallbladder issues. You should contact a doctor immediately if you experience severe abdominal pain, persistent vomiting, or yellowing of the skin or eyes.
Your Hi-Doctor physician will discuss potential side effects with you and advise on when to seek medical attention or consider stopping the medication. Always follow your doctor's instructions and never adjust your dosage without medical advice.
Why Hi-Doctor vs. walking into a clinic
Choosing Hi-Doctor for your weight management medication prescription offers significant advantages over traditional clinic visits:
- Speed: Get your prescription in under 24 hours, compared to weeks of waiting for an in-person appointment.
- Price: A flat €25 consultation fee, regardless of the outcome. No hidden costs or variable private clinic fees.
- Convenience: Everything happens securely within the app from your phone or computer. No travel, no waiting rooms, no time off work.
- Privacy: Your consultation is discreet and confidential, conducted via private, RGPD-compliant chat in your account – no reception desk queues.
- Trust: Join over 50,000 satisfied patients who have rated us 4.8 on Trustpilot. Our EU-licensed doctors provide personalised care.
- Accessibility: Your REMPE prescription is valid at **any pharmacy in the EU**, making it incredibly easy to collect your medication wherever you are.
Frequently asked questions
What happens if the doctor decides I'm not a candidate for the medication?
If our EU-licensed doctor determines that the treatment is not appropriate for your case, your €25 consultation fee is refunded automatically. You pay nothing if the treatment isn't approved.
Is the REMPE prescription valid outside Spain?
Yes, absolutely. REMPE is Spain's official private electronic prescription standard. Under EU Directive 2011/24/EU, any pharmacy in the EU (including France, Germany, Italy, Portugal, Netherlands, Belgium, Austria, Ireland, etc.) is legally obliged to dispense from it. You receive a downloadable PDF you can print or show on your phone.
How do I actually collect the medication once I have the prescription?
Simply print the PDF prescription or show it on your phone at any EU pharmacy. The pharmacist will scan the QR code or verify the digital signature and dispense your medication.
Is it legal to get weight management medication online in my country?
Yes, it is legal to obtain weight management medication online through an EU-licensed doctor who issues a valid REMPE prescription. This prescription is recognised across all EU member states, allowing you to legally collect your medication.
How long does the prescription take?
If the doctor finds the treatment appropriate, you will receive your REMPE electronic prescription (PDF) in your Hi-Doctor account and by email within 24 hours of your consultation.
Is my data private?
Yes, your privacy is our top priority. All your data and consultations are handled in strict compliance with RGPD regulations, ensuring complete confidentiality and security within your private Hi-Doctor account.
How much does it cost?
The online consultation with an EU-licensed doctor costs a flat €25. This fee is refunded if the doctor determines the treatment is not appropriate for you. The cost of the medication itself is paid directly to the pharmacy.